Objective: To assess the pharmacokinetics, toxicity, and efficacy of antineoplastons A10 (NSC 648539) and AS2-1 (NSC 620261). Design: We initiated a phase II trial in order to determine whether evidence of antitumor activity of A10 and AS2-1 could be documented. Material and Methods: Patients with anaplastic astrocytoma or glioblastoma multiforme recurring after radiation therapy were eligible for enrollment in the trial. Patients received escalating doses of A10 and AS2-1 by multiple intermittent intravenous injections with use of a portable programmable pump to the target daily dose of 1.0 g/kg for A10 and of 0.4 g/kg for AS2-1. Results: Nine patients were treated, in six of whom the treatment response was assessable in accordance with protocol stipulations. No patient demonstrated tumor regression. Reversible grade 2 or 3 neurocortical toxicity, consisting of transient somnolence, confusion, and exacerbation of an underlying seizure disorder, was noted in five patients. Mean steady-state plasma concentrations of phenylacetate and phenylacetylglutamine after escalation to the target doses of A10 and AS2-1 were 177 +/-101 @mg/mL and 302 +/- 102 @mg/mL, respectively. Patients who exhibited confusion tended to have higher phenylacetate levels. Conclusion: Although we could not confirm any tumor regression in patients in this study, the small sample size precludes definitive conclusions about treatment efficacy. Antineoplaston-related toxicity was acceptable in most patients with appropriate dose modification, although severe neurocortical toxicity may occur. Steady-state plasma concentrations of phenylacetate with use of A10 and AS2-1 were similar to those reported with use of similar doses of phenylacetate alone.
The luminosities, colors and H\alpha\ emission for 429 HII regions in 54 LSB
galaxies are presented. While the number of HII regions per galaxy is lower in
LSB galaxies compared to star-forming irregulars and spirals, there is no
indication that the size or luminosity function of HII regions differ...
The melting of the three-stranded DNA on a Sierpinski gasket of dimensions d <
2 by assigning extra weight factors to fork openings and closings, to induce a
Two strand DNA melting. In such a context we can find again the existence of
The Efimov-DNA like state but quite surprisingly we disc...
We present a combined numerical and analytical study of pattern formation in
An active system where particles align, possess a density-dependent motility,
And are subject to a logistic reaction. This is a model for suspensions of
Reproducing bacteria, but it can also represent, in the ordered phase,...
Pubget Updates sends you emails when Pubget finds new papers that match your search. Use Pubget Updates to get the latest articles for your specialty, written by a colleague, or published by your favorite journals.